We just started using the new Dynatrace One Agent and have found this same issue on a few of our IIS servers. The problems opened as soon as the IIS process started to report in and the problem details are woefully unhelpful. How can we use Dynatrace to find the actual root cause and fix the issue?
As Felipe said, if .NET iis application is not in use, app pool is suspended. In such case application process can have connectivity error. If your host has no connectivity problems and network traffic is fine, than there is nothing to worry about it. If this happens in the same time every day you can configure maintenance window to suspend problems. But be aware that will suspend all problems related to entities picked for this window.