The most likely cause is that the folder where the AMD tries to store the capture file does not exist. I know that since 12.4.5 this folder changed.
There create the folder spc and give it the same rights (chmod) as the other folders and change owner to compuware (chown).
We tried reproducing this issue so it doesn't happen anymore but it didn't occur in our setup.
Could you provide upgrade.bin.log from location /var/log/adlex ?
Then we could try reproducing this again, this time with exact builds and system.