Handshake failure indicates that the sender was unable to negotiate an acceptable set of security parameters given the options available. This is a fatal error.
Read out the following links for the troubleshooting SSL monitoring issues and SSL decryption troubleshooting guide.
One question, may be due lack of knowledge in this area,
Does HTTP traffic also do handshake while making connection to the app server? If Yes, Can we say that, this dropped handshake belongs to HTTP traffic?