It should, as long as it is a supported version (from processes standpoint) If you are looking to Synthetically monitor that actual site, then yes, internal or external, you should be able to hit it.
Supported Versions:
https://www.dynatrace.com/support/help/technology-support/supported-technologies-and-versions/
Synthetics (Private/Public):
https://www.dynatrace.com/support/help/how-to-use-dynatrace/synthetic-monitoring/
-Chad
