OneAgent auto-injects into all the web applications that are being rendered by the server on which the agent is installed. In the case where you have multiple environments running off the same web server and would like to monitor the performance of some domains and not all, it is just a simple switch flip which will override the default behavior of the OneAgent and not inject into the domain of your choice.
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We have multiple ways of achieving this in Dynatrace:
Once the setting is made, you can be assured that the OneAgent will not auto-inject into the specified domain and also not provide any real user monitoring metrics for the same.